Carboxymethylcellulose Calcium (CMC-Ca) Superdisintegrant | Ike Ịza Ọzịza Dị Elu Maka Mwepụ Ngwa Ngwa Mbadamba | Dabara na USP/EP/ChP

Calcium Carboxymethylcellulose anyị (Carmellose Calcium, CMC-Ca) bụ ihe na-enye ọgwụ dị ọcha nke na-arụ ọrụ dị ka ihe na-agbaze, ihe na-ejikọta ọnụ, na ihe na-agbaze mmiri maka ụdị ọgwụ siri ike a na-aṅụ.Ọ bụ nnu calcium nke carboxymethylcellulose, nke na-apụta dị ka ntụ ntụ hygroscopic ọcha site na ọcha ruo na-acha ọcha nke na-anaghị agbaze na mmiri mana ọ na-aza ngwa ngwa ruo ugboro ugboro olu mbụ ya mgbe ọ metụrụ ihe dị n'ime mmiri aka.Usoro ọzịza pụrụ iche a na-eme ka mbadamba ahụ gbawaa ngwa ngwa ma mee ka ọgwụ ahụ gbazee nke ọma. Uru ndị dị mkpa gụnyere: enweghị sodium (ọ dabara adaba maka ndị ọrịa nwere obi na sodium nke a na-egbochi), mmasi dị mma, yana ndakọrịta na ma usoro mkpakọ kpọmkwem na usoro granulation mmiri . Dabara na ọgwụ USP-NF, EP, JP, na ChP site na ndebanye aha CDE F20230000328. Ọkwa ojiji nkịtị: 0.5-15% w/w.

Kpọtụrụ anyị

Nkọwa Ngwaahịa

Ọgwụ nke ọkwa Carboxymethylcellulose Calcium (Carmellose Calcium, CMC-Ca)

Nchịkọta Ngwaahịa

Carboxymethylcellulose Calcium bụ nnu calcium nke polycarboxymethyl ether nke celluloseỌ bụ ihe na-enye ọgwụ dị iche iche nke a na-ejikarị eme ihe dị ka ihe na-agbaze, ihe na-ejikọta ihe, na ihe na-agbaze ihe n'ụdị ọgwụ siri ike a na-aṅụ, gụnyere mbadamba na kapsụl N'adịghị ka sodium nke ogbo ya, nnu calcium na-enye uru nke usoro enweghị sodium, na-eme ka ọ dabara adaba karịsịa maka ndị ọrịa nwere obi na sodium nke a na-egbochi..

Njirimara Ngwaahịa:

Aha Kemịkalụ:Calcium Carboxymethylcellulose / Calcium Carmellose
Nọmba CAS:9050-04-8
Nọmba Ndebanye Aha CDE:F20230000328
Nrubeisi nke Pharmacopoeia:ChP, USP-NF, EP, JP
Okwu ndị yiri ya:Calcium carboxymethylcellulose, Calcium CMC, CMC-Ca, Carmellose Calcium
ỤFỌDỤ:UTY7PDF93L
Ọdịdị:Ntụ ntụ ọcha ruo na-acha odo odo ma ọ bụ na-acha ọcha, hygroscopic mgbe akpọchara nkụ
Mgbaze:Ọ naghị agbaze na mmiri, acetone, mmanya na toluene; ọ na-aza n'ime mmiri iji mepụta ihe na-egbochi ihe

Atụmatụ na Uru Ndị Dị Mkpa

1. Usoro Mgbasa Kachasị Elu

Mmiri anaghị agbaze mana ọ na-agbasa ngwa ngwa ruoọtụtụ ugboro olu mbụ yamgbe kọntaktị na ihe mgbasa ozi mmiri
Na-emepụta nrụgide mekanik nke na-agbaji mbadamba ngwa ngwa
Na-eme ka ọgwụ ahụ gbawaa ngwa ngwa ma zuru oke maka mgbasa ya nke ọma
Ọ na-arụ ọrụ nke ọma ọbụlagodi na mbadamba siri ike ebe ihe ndị ọzọ na-emebi emebi nwere ike ọ gaghị arụ ọrụ nke ọma

2. Ihe na-arụ ọrụ dị iche iche

Ihe na-akpata ihe mkpofu:Ọrụ bụ isi dị ka ihe na-agbaze mbadamba na njupụta 0.5-15%
Ihe njide:Ihe njide dị irè na usoro nhazi mmiri mmiri
Ihe na-agbaze mmiri/ihe na-emeju ihe:Nwere ike ije ozi dị ka mbadamba ihe na-ebelata shuga
Enyemaka Nkwụsị:A na-eji ya dị ka ihe na-eme ka ihe kwụsie ike n'ihe gbasara ọgwụ ọnụ na nke dị n'elu.

3. Uru Enweghị Sodium

Enweghị sodium - zuru oke maka ọgwụ obi na ndị ọrịa nwere oke sodium
Na-edozi mkpa ndị na-eto eto na ndị ọrịa maka usoro sodium dị ala
Na-agbaso usoro nhazi dị ọcha na nke na-echebara ahụike echiche

4. Ndakọrịta API dị mma

Ọ dị irè karịsịa makaọgwụ cephalosporin, yana njirimara mmezi mgbasa nke egosiri
Nhazi chelating dị mma na-abara ụfọdụ klaasị API uru
Dakọtara na ọtụtụ ihe ndị na-arụ ọrụ dị iche iche gụnyere: Pioglitazone HCl, Aminophylline, Berberine HCl, Milnacipran HCl, Cefixime, Nicorandil, na ọtụtụ ndị ọzọ.

5. Njirimara Anụ Ahụ Kachasị Elu

Nnukwu mkpakọ na ike nke mbadamba
Na-ejigide iguzosi ike n'ezi ihe nke mbadamba ma na-ahụ na ọ na-emebi ngwa ngwa
Ezigbo ihe eji eruba mmiri maka mkpakọ kpọmkwem
Ọ dị mma n'agbanyeghị hygroscopicity - chekwaa ya n'ime akpa ndị e mechiri emechi nke ọma

6. Profaịlụ Iwu na Ogo