Croscarmellose Sodium Superdisintegrant maka mbadamba ọgwụ | Ọzịza ngwa ngwa, Ọkwa ojiji dị ala 0.5-5% | Dabara na USP/EP/JP

Croscarmellose Sodium anyị bụ ihe na-eme ka ọ dị ọcha nke ukwuu nke e mere maka ụdị ọgwụ siri ike a na-aṅụ, gụnyere mbadamba, kapsụl, na granules. Ọ bụ sodium carboxymethylcellulose dị n'ime nke a na-anaghị agbaze n'ime mmiri mana ọ na-agbasa ngwa ngwa ruo ugboro 4-8 nke olu mbụ ya mgbe ọ metụrụ ihe na-eme ka mmiri dị n'ime ya.Ọdịdị pụrụ iche a nke eriri afọ na-enye ikike ịmịcha mmiri na ọrụ capillary dị mma, na-ebute mmebi dị elu na mgbasa ọgwụ ka mma.Dabara na ọgwụ USP-NF, EP, JP, na ChP site na ndebanye aha CDE F20209990136Ọkwa ojiji a na-ejikarị eme ihe: 0.5-5.0% w/w (2% maka mkpakọ kpọmkwem, 3% maka ntụnye mmiri mmiri)Ọ dị mma maka mkpakọ ozugbo, ntụnye mmiri mmiri (n'ime ma ọ bụ n'èzí granular), mkpakọ roller, na usoro kapsụl

Kpọtụrụ anyị

Nkọwa Ngwaahịa

Ọgwụ ọkwa Croscarmellose Sodium (CCS)

Nchịkọta Ngwaahịa

Croscarmellose Sodium bụ sodium carboxymethylcellulose nke nwere njikọ dị n'ime, nke e mere kpọmkwem maka ojiji dị ka ihe na-egbochi ihe mkpofu n'ụdị ọgwụ.N'adịghị ka ihe ndị na-emebi ihe nkịtị, ọ na-enye ihe pụrụ iche na-emebi ihe na obere mkpokọta, na-eme ka mbadamba ngwa ngwa gbasaa ma na-agbaze ọgwụ ka mma maka mmụba bioavailability .

Njirimara Ngwaahịa:

Aha Kemịkalụ:Sodium Croscarmellose
Nọmba CAS:74811-65-7
Nọmba Ndebanye Aha CDE:F20209990136
Nrubeisi nke Pharmacopoeia:ChP, USP-NF, EP, JP, BP
Nọmba EC:629-739-2
Okwu ndị yiri ya:Carboxymethylcellulose Sodium, CCNa, Sodium Croscarmellose, E468

Atụmatụ na Uru Ndị Dị Mkpa

1. Usoro Mgbasa Kachasị Elu

Nkwụsị nke ihe omume abụọ:Na-ejikọta ọrụ capillary (wicking) na ọzịza ngwa ngwa
Na-aza ruoUgboro 4-8 nke olu mbụ yamgbe ha metụrụ mmiri aka
Ọdịdị eriri na-enye ikike ịmịkọrọ mmiri nke ọma
Na-emepụta mgbasawanye igwe nke na-agbaji mbadamba ngwa ngwa

2. Ọkwa Ojiji Dị Ala - Arụmọrụ Dị Elu

Irè na njupụta dị ala dịka0.5-5.0% w/w
Ojiji nkịtị: 2% maka mkpakọ kpọmkwem, 3% maka ntụnye mmiri mmiri
Ngwọta dị ọnụ ala maka mmepe usoro

3. Mgbanwe Nhazi

Dabara adaba maka usoro mbadamba niile: mkpakọ kpọmkwem, granulation mmiri mmiri, mkpakọ roller
N'ime granulation mmiri mmiri, enwere ike iji ya n'ime granular, n'ime granular, ma ọ bụ kewaa ya n'etiti usoro abụọ ahụ.
Dakọtara na usoro capsules (ojiji 10-25%)

4. Njirimara Anụ Ahụ Dị Mma

Ọdịdị:Ntụ ntụ na-agba agba ọcha ruo na-acha ọcha, nke na-agba ọsọ ọsọ
Ogo nke nnọchi:0.60 – 0.85
Olu nhazi:10.0 – 30.0 ml
pH (1% ngwọta):5.0 – 7.0
Mfu mgbe a kpọrọ nkụ:≤10.0%
Ihe fọdụrụ na mgbanye ọkụ:14.0% – 28.0%
Ihe Na-agbaze Mmiri:≤10.0%
Ọla dị arọ:≤10 ppm

5. Ndakọrịta na Ịkwụsi Ike API

Ọ na-emeenweghị peroxide- na-eme ka nkwụsi ike ka mma maka API ndị nwere mmetụta oxidation
Enweghị mmetụta ọjọọ na ike ma ọ bụ friability nke mbadamba
Arụmọrụ mmebi na-anọgide na-agbanwe agbanwe ka oge na-aga
Enweghị GMO, enweghị allergens